Assistant Professor

Oklahoma State University

School of Mechanical and Aerospace Engineering

218 Engineering North

Stillwater, OK 74078-5016

(405) 744-5900

(405) 744-7873 Fax

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Academic Background

Ph.D., Biomedical Engineering, Stony Brook University

M.S., Biomedical Engineering, Stony Brook University

B.E., Biomedical Engineering, Stony Brook University

Areas of Interest

Tissue Engineering of Blood Vessels

Biofluid Flow within the Microcirculation and Macrocirculation

Platelet Activation Potentials

Coagulation Cascade

Nanofabrication

Two-phase, Multi-scale Modeling

Honors and Awards

Award for Academic Excellence in Biomedical Engineering -- Class of 2004

Provosts Award for Academic Excellence -- State University of New York at Stony Brook

Barry M. Goldwater Scholar

Memberships

American Association for the Advancement of Science

Biomedical Engineering Society, BMES

Microcirculation Society

Sigma Xi Research Honor Society

Recent Publications

Biofluid Mechanics: An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation. David A. Rubenstein, Wei Yin and Mary D. Frame. Academic Press: Boston, MA; 2011. (http://www.elsevierdirect.com/ISBN/9780123813831/Biofluid-Mechanics).

Endothelial Cell Adhesion and Growth within a Bioassay Chamber using Microstamped ECM Proteins. David A. Rubenstein and Mary D. Frame. JOM, June 2011; Volume 63, Issue 6: 84-93.

Glycated albumin modulates endothelial cell thrombogenic and inflammatory responses. David A. Rubenstein, Zahra Maria and Wei Yin. Journal of Diabetes Science and Technology, May 2011; Volume 5, Issue 3: 703-713.

The effect of physiologically relevant dynamic shear stress on platelet and endothelial cell activation. Wei Yin, Saravan Kumar Shanmugavelayudam and David A. Rubenstein. Thrombosis Research, 2011; Volume 127: 235-241.

In Vitro Biocompatibility of Sheath-Core Cellulose Acetate Electrospun Scaffolds Towards Endothelial Cells and Platelets. David A. Rubenstein, Subramaniam M. Venkitachalam, Dan Zamfir, Fang Wang, Hongbing Lu, Mary D. Frame and Wei Yin. Journal of Biomaterials Science: Polymer Edition, 2010; Volume 21: 1713-1736.

The combined effects of sidestream smoke extracts and glycated serum albumin on endothelial cells and platelets. David A. Rubenstein, Blake E. Morton and Wei Yin. Cardiovascular Diabetology 2010, 9:28.

Quantifying the Effects of Shear Stress and Shear Exposure Duration Regulation on Flow Induced Platelet Activation and Aggregation. David A. Rubenstein and Wei Yin. Journal of Thrombosis and Thrombolysis: Volume 30, Issue 1 (2010): 36-45.

Effect of geometrical assumptions on numerical modeling of coronary blood flow under normal and disease conditions. Saravan Kumar Shanmugavelayudam, David A. Rubenstein and Wei Yin. Journal of Biomechanical Engineering. 2010, June, Vol. 132, Issue. 6, 061004-1 to 061004-8.

Biocompatibility of Surfactant-Templated Polyurea Nanoencapsulated Templated Silica Aerogel. Wei Yin, Subramaniam M. Venkitachalam, Ellen Jarrett, Sarah Staggs, Nicholas Leventis, Hongbing Lu and David A. Rubenstein. Journal of Biomedical Materials Research: Part A. 2010 March 15; 92(4): 1431-1439.

Dose effect of shear stress on platelet complement activation in a dynamic cone and plate shearing device. Wei Yin & David A. Rubenstein. Cellular & Molecular Bioengineering. June 2009, Vol. 2, No. 2: 274-280.

Glycated Albumin Modulates Platelet Susceptibility to Flow Induced Activation and Aggregation. David A. Rubenstein and Wei Yin. Platelets, May 2009; 20(3): 206-215.

Bioassay chamber for angiogenesis with perfused explanted arteries and electrospun scaffolding. David Rubenstein, Dong Han, Sara Goldgraben, Hebah El-Gendi, Pelagia-Irene Gouma, Mary D Frame. Microcirculation 2007:14, 723-737.

Platelet factor V supports hemostasis in a patient with an acquired factor V inhibitor, as shown by prothrombinase and tenase assays. Maria T. Grosse Perdekamp, MD, David A. Rubenstein, Jolyon Jesty, PhD, Mae B. Hultin, MD. Blood Coagulation & Fibrinolysis 2006; Vol. 17, Issue October: 593-597.

Activation of platelets exposed to shear stress in the presence of smoke extracts of low-nicotine and zero-nicotine cigarettes: the protective effect of nicotine. Jaimohan Ramachandran, David Rubenstein, Danny Bluestein, Jolyon Jesty. Nicotine and Tobacco Research. 2004; Vol. 6, No 5, Issue October: 835-841.

A shear-restricted pathway of platelet procoagulant activity is regulated by IQGAP1. Wadie Bahou, Lesley Scudder, David Rubenstein, Jolyon Jesty. Journal of Biological Chemistry. 2004; Vol. 279, No 21, Issue May 21: 22571-22577.

Differences between mainstream and sidestream cigarette smoke extracts and nicotine in the activation of platelets under static and flow conditions. David Rubenstein; Jolyon Jesty, Danny Bluestein. Circulation. 2004; 109: 78-83.

Effects of physiologically relevant dynamic shear stress on platelet complement activation. Saravan Kumar Shanmugavelayudam, David A. Rubenstein and Wei Yin. Accepted to Platelets (4/2011).

Characterization of the Physical Properties and Biocompatibility of Polybenzoxazine Based Aerogels for use as a Novel Hard Tissue Scaffold. David A. Rubenstein, Hongbing Lu, Shruti S. Mahadik, Nicholas Leventis and Wei Yin. Accepted to Journal of Biomaterials Science: Polymer Edition (April 2011).

Characterization of the biocompatibility and mechanical properties of polyurea organic aerogels with blood and vascular endothelial cells -- aerogel potential applications in blood implantable devices. Wei Yin, Hongbing Lu, Nicholas Leventis and David A. Rubenstein. Submitted to Journal of Biomedical Materials Research: Part A (April 2011).

Endothelial cells and dynamic shear stress patterns affect platelet surface P-selectin and GPIba expression. Wei Yin, Farzana Rouf and David A. Rubenstein. Submitted to Thrombosis and Haemostasis (August 2011).

Glycated albumin and pathological shear stress alters endothelial cell thrombogenic potential, pro-inflammatory state and cytoskeletal dynamics. Zahra Maria, Wei Yin and David A. Rubenstein. Submitted to Experimental Diabetes Research (August 2011).

Reviewer For

Microcirculation

Annals of Biomedical Engineering

Nicotine and Tobacco Research

Journal of Heat Transfer

Journal of Thrombosis and Haemostasis

Thrombosis Research

National Science Foundation - BME Panel

American Heart Association - Vascular Wall Biology Panel